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Related Experiment Video

Updated: Feb 7, 2026

Force and Position Control in Humans - The Role of Augmented Feedback
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A positive feedback loop bi-stably activates fibroblasts.

So-Young Yeo1, Keun-Woo Lee1, Dongkwan Shin2

  • 1Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, 06351, Republic of Korea.

Nature Communications
|August 3, 2018
PubMed
Summary
This summary is machine-generated.

A newly identified Twist1-Prrx1-TNC positive feedback loop (PFL) drives fibroblast activation in fibrosis and cancer. This PFL acts as a bistable switch, potentially offering a fibroblast-specific therapeutic target.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Systems Biology

Background:

  • Fibroblasts are typically dormant but can become perpetually activated in fibrosis and cancer.
  • The regulatory network governing fibroblast activation dynamics remains largely unknown.

Purpose of the Study:

  • To identify the key regulatory network controlling fibroblast activation.
  • To investigate the role of Twist1, Prrx1, and Tenascin-C (TNC) in fibroblast dynamics.

Main Methods:

  • Systems biology approaches
  • Analysis of the Twist1-Prrx1-TNC regulatory network
  • In vivo studies of fibrotic nodules

Main Results:

  • A Twist1-Prrx1-TNC positive feedback loop (PFL) was identified.
  • This PFL functions as a bistable switch regulating fibroblast activation.
  • The PFL can be irreversibly activated in pathological conditions, leading to sustained fibroblast activation and fibrotic changes.

Conclusions:

  • The Twist1-Prrx1-TNC PFL is crucial for perpetual fibroblast activation in fibrosis and cancer stroma.
  • This PFL represents a fibroblast-specific therapeutic target for deprogramming activated fibroblasts.