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Trihexyphenidyl Misuse in Delusional Disorder.

Pankaj Mahal1, K N Nishanth1, Ananya Mahapatra1

  • 1Department of Psychiatry and NDDTC, All India Institute of Medical Sciences, New Delhi, India.

Journal of Neurosciences in Rural Practice
|August 3, 2018
PubMed
Summary

Trihexyphenidyl, an anticholinergic drug, is sometimes abused for its euphoric effects. This case study explores its misuse in patients with delusional disorders, highlighting diagnostic challenges and its potential as a psychoactive substance.

Keywords:
Delusional disorderdependencemisusetrihexyphenidyl

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Substance Use Disorders

Background:

  • Trihexyphenidyl is prescribed to manage antipsychotic-induced extrapyramidal symptoms.
  • Reports suggest potential for abuse, with users experiencing pleasure and relaxation.

Observation:

  • Two cases of trihexyphenidyl misuse are presented.
  • Misuse occurred in patients with persistent delusional disorders.

Findings:

  • The cases illustrate the challenges in diagnosing trihexyphenidyl misuse within the context of psychotic disorders.
  • This highlights the need to consider trihexyphenidyl as a potential psychoactive substance.

Implications:

  • Further clarification is needed on classifying trihexyphenidyl misuse under substance use disorders.
  • Clinicians should be vigilant for trihexyphenidyl abuse in patients with delusional disorders.