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False Positive Troponin I Rendering Two Admissions for "Recurrent Acute Myopericarditis".

Rita Marinheiro1, Pedro Amador1, Leonor Parreira1

  • 1Cardiology Department, Centro Hospitalar de Setúbal, Setúbal, Portugal.

The Open Cardiovascular Medicine Journal
|August 3, 2018
PubMed
Summary
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False positive cardiac troponin I results can occur due to alkaline phosphatase interference. This case highlights the importance of considering assay interference in diagnosing conditions like myopericarditis.

Area of Science:

  • Clinical Chemistry
  • Cardiology
  • Diagnostic Assays

Background:

  • Cardiac troponin I assays are widely used for diagnosing myocardial infarction.
  • The incidence of false positive results is not well-established due to numerous manufacturers.
  • Recurrent myopericarditis can present with symptoms mimicking cardiac events.

Observation:

  • An 18-year-old patient with a history of myopericarditis presented with recurrent symptoms.
  • Cardiac troponin I levels were elevated, initially suggesting a cardiac event.
  • Further investigation revealed interference in the troponin assay.

Findings:

  • The elevated cardiac troponin I levels were determined to be false positives.
  • Alkaline phosphatase interference was identified as the cause of the false positive results.
Keywords:
Alkaline phosphataseAssayEchocardiographyFalse positiveMyopericarditisTroponin I

Related Experiment Videos

  • This interference impacted the diagnostic accuracy of the troponin I assay.

    • Implications:

    • Clinicians should be aware of potential interferences in cardiac troponin I assays.
    • Alkaline phosphatase interference can lead to misdiagnosis and inappropriate treatment.
    • Consideration of assay interference is crucial for accurate diagnosis, especially in patients with specific clinical histories.