Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Membrane antigen expression during hemopoietic differentiation.

C A Sieff

    Critical Reviews in Oncology/Hematology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease.

    Blood·2001
    Same author

    Congenital bone marrow failure syndromes.

    British journal of haematology·2000
    Same author

    Maturation and lineage-specific expression of the coxsackie and adenovirus receptor in hematopoietic cells.

    Stem cells (Dayton, Ohio)·2000
    Same author

    Diamond-Blackfan anemia.

    Current opinion in hematology·2000
    Same author

    Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.

    Genes & development·2000
    Same author

    Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level.

    The Journal of experimental medicine·1999
    Same journal

    Remodeling the Immune Microenvironment: Engineering IL-2 Variants to Overcome Clinical Bottlenecks in PD-1 Inhibitor plus Chemotherapy.

    Critical reviews in oncology/hematology·2026
    Same journal

    Neoadjuvant Immunotherapy in Melanoma: From Pathologic Response to Response-Adapted Management.

    Critical reviews in oncology/hematology·2026
    Same journal

    DNA polymerase epsilon catalytic subunit (POLE) in cancer: Implications for tumor biology and therapeutic strategies - A comprehensive review.

    Critical reviews in oncology/hematology·2026
    Same journal

    Long non-coding RNAs in triple-negative breast cancer: emerging drivers of tumor biology, prognosis, and drug resistance.

    Critical reviews in oncology/hematology·2026
    Same journal

    Alternative splicing in breast cancer drug resistance: Mechanisms, therapeutic targeting, and clinical translation.

    Critical reviews in oncology/hematology·2026
    Same journal

    Gene fusions in non-small cell lung carcinoma (NSCLC): Expert perspectives and practical considerations for routine testing.

    Critical reviews in oncology/hematology·2026
    See all related articles

    Changes in cell surface antigens during hematopoietic stem cell differentiation offer insights into stem cell selection, leukemia classification, and therapeutic strategies like preventing graft-versus-host disease.

    Area of Science:

    • Hematopoiesis research
    • Immunology
    • Cellular biology

    Background:

    • Cell surface antigen expression varies with hematopoietic stem cell differentiation and proliferation.
    • Understanding these antigen patterns is crucial for advancing stem cell biology.

    Purpose of the Study:

    • To review the cellular basis of hematopoiesis.
    • To discuss methods for identifying antigens on normal hematopoietic cells.
    • To summarize antigen expression patterns during differentiation and their implications.

    Main Methods:

    • Review of existing literature on hematopoietic stem cell differentiation.
    • Analysis of cell surface antigen expression patterns.
    • Discussion of immunological and therapeutic applications.

    Related Experiment Videos

    Main Results:

    • Emerging map of antigen expression changes during hematopoietic differentiation.
    • Identification of antigens for rare stem cell selection and purification.
    • Application in acute leukemia classification.

    Conclusions:

    • Knowledge of antigen patterns aids in stem cell purification and leukemia diagnosis.
    • Therapeutic uses include preventing graft-versus-host disease and purging leukemic cells.
    • Further insights into physiological and pathological cellular interactions in early hematopoiesis.