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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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The importance of fetuin-A in vascular calcification in children with chronic kidney disease

Irena Makulska1, Maria Szczepańska2, Dorota Drożdż3

  • 1Department of Pediatric Nephrology, Faculty of Medicine, Wroclaw Medical University, Poland.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|August 3, 2018
PubMed

Insights

Children with chronic kidney disease (CKD) have lower fetuin-A levels, linked to vascular calcification risk factors. Lower fetuin-A may help identify those at risk for vascular disease.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health in CKD
  • Biochemistry of Calcification

Background:

  • Arterial stiffness significantly impacts cardiovascular health in pediatric chronic kidney disease (CKD).
  • Reduced levels of soft tissue calcification inhibitors contribute to vascular calcification in children with CKD.

Purpose of the Study:

  • To investigate the role of fetuin-A in vascular wall hardening in pediatric CKD.
  • To assess serum fetuin-A levels in relation to renal function, dialysis type, and vascular calcification markers.

Main Methods:

  • A cross-sectional study involving 20 children on peritoneal dialysis (PD), 20 on hemodialysis (HD), 36 on conservative treatment, and 26 healthy controls.
  • Measurement of serum fetuin-A, clinical, and biochemical parameters in all participants.

Main Results:

  • Children on hemodialysis (HD) exhibited significantly lower fetuin-A concentrations compared to PD, conservative, and control groups.
  • In pediatric CKD patients, fetuin-A negatively correlated with dialysis vintage, pulse wave velocity/height (PWV/ht), phosphate, calcium-phosphate product (CaxP), and vitamin D3 doses.
  • Across the entire study population, fetuin-A showed negative correlations with blood pressure (BP), PWV/ht, intact parathyroid hormone (iPTH), high-sensitivity C-reactive protein (hsCRP), and cholesterol.

Conclusions:

  • Decreased fetuin-A concentrations in pediatric CKD are associated with established vascular calcification risk factors.
  • Serum fetuin-A may serve as a valuable marker for identifying vascular disease risk in children with CKD.
Abstract

Keywords:
childrenchronic kidney diseasefetuin-A

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