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Validation of the preference-based multiple sclerosis index.

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  • 1School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.

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|August 3, 2018
PubMed
Summary
This summary is machine-generated.

The preference-based multiple sclerosis index (PBMSI) demonstrates strong construct validity for measuring health-related quality of life (HRQL) in multiple sclerosis (MS) patients. This validated tool can effectively compare interventions for individuals with MS.

Keywords:
Preference-based measurespatient-reported outcomesquality of life

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Area of Science:

  • Health outcomes research
  • Clinical epidemiology
  • Psychometrics

Background:

  • Preference-based measures of health-related quality of life (HRQL) are crucial in multiple sclerosis (MS) research.
  • Existing HRQL measures in MS have limitations that require addressing.

Purpose of the Study:

  • To evaluate the structural, convergent, and known-groups validity of the preference-based multiple sclerosis index (PBMSI) for HRQL in people with MS.
  • To establish the PBMSI as a reliable outcome measure for MS research.

Main Methods:

  • Recruitment from three MS clinics in Montreal.
  • Structural validity assessed via factor analysis and polychoric correlation coefficients.
  • Convergent and known-groups validity tested against other HRQL measures and disability levels.

Main Results:

  • Factor analysis confirmed the structural validity of the PBMSI, indicating it measures a single underlying construct.
  • The PBMSI demonstrated convergent validity with generic HRQL measures.
  • Known-groups validity was established, differentiating between individuals with varying disability levels.

Conclusions:

  • The PBMSI is a valid construct for assessing HRQL in MS.
  • The PBMSI offers advantages over current HRQL measures in MS.
  • The PBMSI can be utilized to compare different interventions for people with MS.