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Temporal variation of Staphylococcus aureus clonal complexes in atopic dermatitis: a follow-up study
M-L Clausen1, S M Edslev2, L B Nørreslet1
1Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, 2 tvaervej, opg. 9, 2. sal, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
The British Journal of Dermatology
|August 3, 2018
Summary
Temporal variations in Staphylococcus aureus (S. aureus) clonal complex (CC) type are linked to flares in atopic dermatitis (AD) disease severity. Changes in S. aureus CC type correlated with increased AD severity, while persistent colonization showed a reduction.
Area of Science:
- Dermatology
- Microbiology
- Genetics
Background:
- Atopic dermatitis (AD) severity is strongly linked to Staphylococcus aureus skin colonization.
- Understanding the dynamics of S. aureus colonization is crucial for managing AD.
Purpose of the Study:
- To investigate temporal changes in S. aureus colonization and clonal complex (CC) types in adult AD patients.
- To explore associations between S. aureus CC type, AD severity (SCORAD), skin barrier function (TEWL, pH), and filaggrin gene (FLG) mutations.
Main Methods:
- Follow-up study of 101 adult AD patients.
- Collection of bacterial swabs from lesional, non-lesional skin, and nose at baseline and follow-up.
- Characterization of S. aureus isolates by spa typing to determine CC type, alongside assessment of SCORAD, TEWL, pH, and FLG mutations.
Main Results:
- Of 63 follow-up participants, 43% were colonized at both visits.
- 52% of persistently colonized patients maintained the same S. aureus CC type.
- A change in CC type was associated with a significant increase in SCORAD (10.7 points), whereas stable CC type correlated with a SCORAD decrease (4.4 points).
- Higher skin pH was observed in patients colonized at both visits; CC type changes were not linked to TEWL, pH, or FLG mutations.
Conclusions:
- Temporal shifts in S. aureus CC type are associated with AD disease flares.
- S. aureus colonization dynamics may play a role in the exacerbation and management of atopic dermatitis.
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