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Regulation of human mitogen-activated protein kinase 15 (extracellular signal-regulated kinase 7/8) and its

Andy T Y Lau1, Yan-Ming Xu1

  • 1Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.

Journal of Cellular Physiology
|August 3, 2018
PubMed

Insights

Mitogen-activated protein kinase 15 (MAPK15) is a newly discovered atypical MAPK involved in cell proliferation, apoptosis, and genome stability. Its dual role as a potential proto-oncogene or tumor suppressor requires further investigation.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Mitogen-activated protein kinase 15 (MAPK15), also known as extracellular signal-regulated kinase 7/8, is the least understood atypical MAPK.
  • MAPK15 has been implicated in diverse cellular processes, including proliferation, transformation, apoptosis, autophagy, cell division, ciliogenesis, protein secretion, and genome stability.

Purpose of the Study:

  • To review and discuss the recent literature on human MAPK15.
  • To elucidate the multifaceted functions of MAPK15 in various cellular activities.
  • To address the unresolved question of whether MAPK15 functions as a proto-oncogene or a tumor suppressor.

Main Methods:

  • Literature review of studies involving human MAPK15.
  • Analysis of experimental data from various cell lines and model systems.
  • Synthesis of findings regarding MAPK15's diverse cellular roles.

Main Results:

  • MAPK15 plays significant roles in cell proliferation, transformation, and apoptosis.
  • MAPK15 is involved in regulating cell division, ciliogenesis, protein secretion, and maintaining genome stability.
  • The specific function of MAPK15 in cancer (proto-oncogene vs. tumor suppressor) remains undetermined due to its complex roles.

Conclusions:

  • MAPK15 is a critical regulator of numerous fundamental cellular processes.
  • Further research is necessary to definitively characterize MAPK15's role in oncogenesis.
  • Understanding MAPK15's functions is crucial for potential therapeutic strategies in cancer.
Keywords:
extracellular signal-regulated kinase 7/8 (ERK7/8)mitogen-activated protein kinase 15 (MAPK15)post-translational modifications (PTMs)

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