Randomized exploratory study to measure ion release from calcium sodium phosphosilicate-containing dentifrice

Area of Science:

• Oral Health
• Biochemistry
• Materials Science

Background:

• Salivary ion concentrations are crucial for oral health.
• Calcium sodium phosphosilicate (CSPS) is a biomaterial used in dental products.
• Understanding CSPS interaction with saliva is important for product development.

Purpose of the Study:

• To investigate salivary concentrations of silicon, calcium, sodium, and phosphorous after using a CSPS-containing dentifrice.
• To assess the oral retention of CSPS from dentifrice and slurry formulations.
• To measure changes in salivary ionic composition over a 60-minute period.

Main Methods:

• Participants used dentifrice with 5% CSPS, 0% CSPS, or a 5% CSPS/glycerol slurry.
• Saliva samples were collected at baseline and at 2, 5, 15, and 60 minutes post-use.
• Inductively coupled plasma optical emission spectroscopy analyzed salivary ion concentrations.

Main Results:

• CSPS-containing products significantly increased salivary silicon compared to the control.
• Salivary calcium increased post-use with CSPS products, while decreasing with the 0% CSPS dentifrice.
• Salivary sodium increased with all treatments, and phosphorous decreased transiently with all treatments.

Conclusions:

• It is possible to measure salivary ionic changes resulting from oral retention of CSPS.
• CSPS dentifrices effectively deliver ions into saliva.
• This study provides evidence for the salivary interaction of CSPS-based dental products.