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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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Role of fibroblast growth factor receptor 4 in cancer

Shuya Tang1, Yilong Hao1, Yao Yuan1

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Cancer Science
|August 3, 2018
PubMed

Insights

Fibroblast growth factor receptor 4 (FGFR4) signaling is crucial in development and cancer. This review summarizes recent findings on FGFR4

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Fibroblast growth factor receptors (FGFR) are vital for embryonic development and adult physiological processes.
  • FGFR signaling pathways regulate diverse biological functions.
  • Dysregulation of FGFR signaling is implicated in various human cancers.

Purpose of the Study:

  • To review recent advancements in understanding Fibroblast growth factor receptor 4 (FGFR4).
  • To explore FGFR4's structure, signaling, physiological roles, and aberrant regulation in cancer.
  • To discuss FGFR4's potential as an anticancer therapeutic target.

Main Methods:

  • Literature review of recent scientific findings on FGFR4.
  • Synthesis of information regarding FGFR4's molecular mechanisms and cancer relevance.
  • Analysis of potential therapeutic strategies targeting FGFR4.

Main Results:

  • FGFR4 plays a significant role in diverse biological processes.
  • Aberrant FGFR4 signaling is increasingly recognized in numerous cancers.
  • Recent research highlights FGFR4's involvement in cancer development and progression.

Conclusions:

  • FGFR4 is a critical factor in both normal physiology and oncogenesis.
  • Targeting FGFR4 presents a promising avenue for novel cancer therapies.
  • Further research into FGFR4 signaling pathways is warranted for therapeutic development.
Keywords:
aberrant signaling pathwaycancerdysregulationfibroblast growth factor receptor 4therapeutic target

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