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Updated: Feb 7, 2026
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Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
Published on: July 11, 2025
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Recent advances in devices for vagus nerve stimulation
Ann Mertens1, Robrecht Raedt1, Stefanie Gadeyne1
1a Department of Neurology , Ghent University Hospital , Gent , Belgium.
Expert Review of Medical Devices
|August 3, 2018
Summary
Novel vagus nerve stimulation (VNS) devices offer improved epilepsy and depression treatment. Research explores VNS for other conditions and noninvasive methods, showing promising results with minimal side effects.
Area of Science:
- Neurology
- Biomedical Engineering
Background:
- Vagus nerve stimulation (VNS) is an established therapy for refractory epilepsy and depression.
- Current VNS technology aims to enhance clinical efficacy and reduce side effects.
Purpose of the Study:
- To review novel VNS device technology, including closed-loop systems and noninvasive approaches.
- To discuss expanding indications for VNS and the ongoing investigation into its mechanisms of action.
Main Methods:
- Review of recently developed VNS therapy systems (AspireSR®, SenTiva™) with cardiac-based seizure detection.
- Exploration of preclinical research on VNS effects on brain plasticity, autonomic nervous system, and inflammation.
- Examination of emerging noninvasive VNS devices.
Main Results:
- Novel VNS devices incorporate closed-loop systems and cardiac-based seizure detection.
- Preclinical data suggest VNS influences brain plasticity, autonomic function, and inflammation.
- Investigational uses for VNS include stroke rehabilitation, heart failure, and rheumatoid arthritis.
Conclusions:
- VNS technology is advancing with novel devices and noninvasive approaches.
- Promising results from animal and human trials indicate minimal adverse events.
- Further research is necessary to validate new VNS devices and optimize stimulation parameters.
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