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Scopolamine increases perseveration in mice subjected to the detour test
Grzegorz R Juszczak1, Rafał Stryjek2
1Department of Animal Behavior, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, 05-552, Jastrzebiec, 36a Postepu str., Poland.
Behavioural Brain Research
|August 3, 2018
Summary
Aging impairs problem-solving due to increased perseveration. This study found the anticholinergic drug scopolamine worsened perseveration in mice, highlighting the role of muscarinic receptors in cognitive control.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Pharmacology
Background:
- Aging is linked to increased perseveration, hindering problem-solving abilities.
- Cholinergic system dysfunction progresses with age, impacting cognitive functions.
Purpose of the Study:
- To investigate the effect of an anticholinergic drug on perseveration levels in mice.
- To determine the role of muscarinic receptors in cognitive control and perseveration.
Main Methods:
- Mice were subjected to a detour test, requiring them to inhibit visually guided behavior.
- The anticholinergic drug scopolamine was administered to assess its impact on perseveration.
- Perseveration was measured by the failure to inhibit prepotent motivational drive and move around a barrier.
Main Results:
- Scopolamine significantly increased perseveration in mice during the detour task.
- This finding suggests the involvement of muscarinic receptors in regulating perseveration.
- The mouse detour task proved effective in detecting anticholinergic drug effects on perseveration.
Conclusions:
- Muscarinic receptor pathways are implicated in the control of perseveration.
- Anticholinergic drugs like scopolamine can exacerbate perseverative behaviors.
- The mouse detour test is a valuable model for studying anticholinergic drug effects on cognitive flexibility.
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