Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sodium Nitroprusside as a Hyperinflation Drug and Therapeutic Alternatives.

Journal of pharmacy practice·2018

Same author

Denial of long-term issues with agriculture on tropical peatlands will have devastating consequences.

Global change biology·2016

Same author

Identification of a cellulose synthase-associated protein required for cellulose biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America·2010

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 7, 2026

Vascular Casting of Adult and Early Postnatal Mouse Lungs for Micro-CT Imaging

Vascular Casting of Adult and Early Postnatal Mouse Lungs for Micro-CT Imaging

Published on: June 20, 2020

Hyperinflation of Nitroprusside.

Alex Cobb¹, Luciana Thornton²

¹1 St. John Medical Center, Tulsa, OK, USA.

Journal of Pharmacy Practice

|August 4, 2018

Summary

Sodium nitroprusside (SNP) price surges created challenges. Clevidipine and nicardipine offer effective, cost-saving alternatives for acute hypertension management.

Area of Science:

Pharmacology
Health Economics
Clinical Pharmacy

Background:

Sodium nitroprusside (SNP) was a cost-effective intravenous vasodilator for acute hypertension.
Between 2013-2017, SNP prices dramatically increased, classifying it as a "hyperinflation drug."
Rising SNP costs present significant challenges for hospital pharmacy departments.

Purpose of the Study:

To review evidence for clevidipine and nicardipine as alternatives to SNP.
To provide strategies for implementing therapeutic interchange of these agents.
To address the challenges posed by hyperinflation drugs in clinical practice.

Main Methods:

Literature review of studies comparing SNP, clevidipine, and nicardipine.
Analysis of pharmacokinetic and safety profiles of alternative agents.

Keywords:

intravenous nitroprusside

More Related Videos

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

Myocardial Infarction and Functional Outcome Assessment in Pigs

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

Related Experiment Videos

Last Updated: Feb 7, 2026

Vascular Casting of Adult and Early Postnatal Mouse Lungs for Micro-CT Imaging

Vascular Casting of Adult and Early Postnatal Mouse Lungs for Micro-CT Imaging

Published on: June 20, 2020

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

Myocardial Infarction and Functional Outcome Assessment in Pigs

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

Examination of hospital case studies on therapeutic interchange outcomes.

Main Results:

Clevidipine and nicardipine are effective IV titratable antihypertensive agents.
These alternatives have favorable pharmacokinetic and safety profiles compared to SNP.
Hospitals substituting clevidipine or nicardipine for SNP reported cost savings without adverse events.

Conclusions:

Clevidipine and nicardipine are viable therapeutic alternatives to SNP for acute hypertension.
Successful implementation of therapeutic interchange requires multidisciplinary collaboration.
Addressing hyperinflation drugs like SNP is crucial for sustainable healthcare.