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Amoxicillin/clavulanic acid-induced pancreatitis: case report
Sana Chams1, Skye El Sayegh2, Mulham Hamdon2
1Department of Internal Medicine, Wayne State University School of Medicine, Rochester Hills, MI, USA. schams@med.wayne.edu.
BMC Gastroenterology
|August 4, 2018
Summary
Amoxicillin/clavulanic acid can cause drug-induced pancreatitis (DIP). This case highlights the importance of considering this antibiotic as a cause of pancreatitis, especially after excluding other common etiologies.
Area of Science:
- Gastroenterology
- Pharmacology
- Internal Medicine
Background:
- Acute pancreatitis is a significant cause of hospitalization, with drug-induced pancreatitis (DIP) incidence often underestimated.
- Inadequate reporting of DIP cases hinders understanding of its true prevalence and associated agents.
Observation:
- A previously healthy male developed acute pancreatitis after a 9-day course of amoxicillin/clavulanic acid for dental prophylaxis.
- Clinical presentation included abdominal pain, nausea, elevated lipase, amylase, and CRP, with CT confirming mild pancreatitis.
Findings:
- Amoxicillin/clavulanic acid was identified as the likely cause of pancreatitis after excluding alcohol, gallstones, hypertriglyceridemia, and hypercalcemia.
- The patient experienced symptom resolution with conservative management, including IV hydration and bowel rest.
Implications:
- This case underscores the necessity of considering amoxicillin/clavulanic acid in the differential diagnosis of acute pancreatitis.
- Increased physician awareness and reporting of DIP cases are crucial for better diagnosis and management.
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