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Methodologies of Neuroepigenetic Research: Background, Challenges and Future Perspectives
Clara Snijders1, Katherine C Bassil1, Laurence de Nijs1
1School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Progress in Molecular Biology and Translational Science
|August 4, 2018
Summary
Neuroepigenetics studies brain epigenetic marks like DNA methylation and histone modifications. This chapter reviews current techniques, challenges, and future directions for understanding brain function and disease.
Area of Science:
- Neuroscience
- Epigenetics
Background:
- Interest in epigenetic mechanisms in neuroscience has surged.
- Neuroepigenetics examines epigenetic marks in the healthy and diseased brain.
Purpose of the Study:
- Summarize techniques for studying brain epigenetic mechanisms.
- Provide an overview of current challenges and future perspectives in neuroepigenetics.
Main Methods:
- Assessment of DNA (hydroxy)methylation.
- Analysis of diverse post-translational histone modifications.
- Study of non-coding RNAs in the brain.
Main Results:
- Increased understanding of epigenetic marks in the brain.
- Identification of various techniques applicable to neuroepigenetics.
- Outline of existing challenges in the field.
Conclusions:
- Neuroepigenetics is a rapidly evolving field.
- Advancements in techniques are crucial for future progress.
- Addressing current challenges will propel the field forward.
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