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Updated: Feb 7, 2026
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Arterial Spin-Labeling in Children with Brain Tumor: A Meta-Analysis
A F Delgado1, F De Luca2, P Hanagandi3
1From the Departments of Clinical Neuroscience (Anna F.D.) anna.falk-delgado@sll.se.
Background:
The value of arterial spin-labeling in a pediatric population has not been assessed in a meta-analysis.
Purpose:
Our aim was to assess the diagnostic accuracy of arterial spin-labeling-derived cerebral blood flow to discriminate low- and high-grade tumors.
Data Sources:
MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Library were used.
Study Selection:
Pediatric patients with arterial spin-labeling MR imaging with verified neuropathologic diagnoses were included.
Data Analysis:
Relative CBF and absolute CBF and tumor grade were extracted, including sequence-specific information. Mean differences in CBF between low- and high-grade tumors were calculated. Study quality was assessed.
Data Synthesis:
Data were aggregated using the bivariate summary receiver operating characteristic curve model. Heterogeneity was explored with meta-regression and subgroup analyses. The study protocol was published at PROSPERO (CRD42017075055). Eight studies encompassing 286 pediatric patients were included. The mean differences in absolute CBF were 29.62 mL/min/100 g (95% CI, 10.43-48.82 mL/min/100 g), I2 = 74, P = .002, and 1.34 mL/min/100 g (95% CI, 0.95-1.74 mL/min/100 g), P < .001, I2 = 38 for relative CBF. Pooled sensitivity for relative CBF ranged from 0.75 to 0.90, and specificity, from 0.77 to 0.92 with an area under curve = 0.92. Meta-regression showed no moderating effect of sequence parameters TE, TR, acquisition time, or ROI method.
Limitations:
Included tumor types, analysis method, and original data varied among included studies.
Conclusions:
Arterial spin-labeling-derived CBF measures showed high diagnostic accuracy for discriminating low- and high-grade tumors in pediatric patients with brain tumors. The relative CBF showed less variation among studies than the absolute CBF.
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