Biogenic Nanosilver against Multidrug-Resistant Bacteria (MDRB)
Caio H N Barros1, Stephanie Fulaz2, Danijela Stanisic3
1Laboratory of Chemical Biology, Institute of Chemistry, State University of Campinas, Campinas 13083-970, Brazil. caionasibarros@gmail.com.
Antibiotics (Basel, Switzerland)
|August 4, 2018
Summary
Biogenic silver nanoparticles (AgNPs) offer a novel approach to combat multidrug-resistant bacteria (MDRB). This review explores their antimicrobial mechanisms and potential in fighting resistant infections.
Area of Science:
- Nanotechnology
- Microbiology
- Materials Science
Background:
- Multidrug-resistant bacteria (MDRB) pose a significant threat to global health due to their resistance to conventional antibiotics.
- The increasing prevalence of antibiotic resistance necessitates the exploration of alternative antimicrobial strategies.
- Nanomaterials, particularly silver nanoparticles (AgNPs), have emerged as promising candidates for antimicrobial applications.
Purpose of the Study:
- To review the latest advancements in biogenic silver nanoparticles (AgNPs) for combating multidrug-resistant bacteria (MDRB).
- To elucidate the antimicrobial mechanisms of AgNPs against MDRB.
- To discuss potential bacterial resistance mechanisms to silver and future directions for AgNP-based therapies.
Main Methods:
- Literature review of recent studies on biogenic AgNPs and their antimicrobial activity.
- Analysis of reported mechanisms of action for AgNPs against MDRB.
- Examination of studies investigating bacterial silver resistance traits.
Main Results:
- Biogenic AgNPs demonstrate significant bactericidal and bacteriostatic effects against a range of MDRB.
- Multiple antimicrobial mechanisms of AgNPs include membrane disruption, oxidative stress induction, and interference with cellular processes.
- Bacteria can acquire resistance to silver through various mechanisms, highlighting the need for careful design of AgNP-based treatments.
Conclusions:
- Biogenic AgNPs represent a promising alternative or adjunct therapy against MDRB infections.
- Understanding AgNP mechanisms and bacterial resistance is crucial for developing effective AgNP-containing products.
- Further research into novel AgNP formulations and delivery systems is warranted to overcome resistance and enhance efficacy.
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