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Updated: Feb 7, 2026

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
Published on: June 7, 2024
Nanoparticle-Based Systems for Delivery of Protein Therapeutics to the Spinal Cord
1Department of Molecular and Cellular Biology, Harvard College, Harvard University, Cambridge, MA, United States.
Abstract:
Recent studies have demonstrated that delivery of protein therapeutics to the spinal cord may promote functional axon regeneration, providing a pathway for recovery of certain motor skills. The timeframe for delivery of protein therapeutics, however, must be modulated to prevent bulk release of the therapeutics and minimize the frequency of implantations. This perspective examines both affinity-based and nanoparticle-based strategies for delivery of neurotrophic factors (NFs) to the spinal cord in an effective, safe, and tunable manner.
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