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Updated: Feb 7, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Autophagy and Rheumatoid Arthritis: Current Knowledges and Future Perspectives
Marta Vomero1, Cristiana Barbati1, Tania Colasanti1
1Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Abstract:
Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens. Deregulation of autophagic pathway has recently been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis (RA). Indeed, autophagy seems to be involved in the generation of citrullinated peptides, and also in apoptosis resistance in RA. In this review, we summarize the current knowledge on the role of autophagy in RA and discuss the possibility of a clinical application of autophagy modulation in this disease.
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