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Related Experiment Video

Updated: Feb 7, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

MRI in predicting conversion to multiple sclerosis within 1 year.

Ayelet Eran¹, Melissa García², Robair Malouf³

¹Neuroradiology Unit, Radiology Department, Rambam Health Care Campus, Haifa, Israel.

Brain and Behavior

|August 4, 2018

Summary

This summary is machine-generated.

Early MRI findings in clinically isolated syndrome (CIS) can predict multiple sclerosis (MS) conversion. Lesion characteristics like number, location, and size indicate a higher risk of developing MS within a year.

Keywords:

demyelinating disease multiple sclerosis neuroimaging

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Published on: December 26, 2015

Area of Science:

Neurology
Radiology
Neuroimaging

Background:

Multiple sclerosis (MS) often begins with a clinically isolated syndrome (CIS).
Predicting conversion from CIS to MS is crucial for timely intervention.
Current prognostic factors require further validation and refinement.

Purpose of the Study:

To validate existing imaging and clinical findings in CIS patients.
To identify novel MRI markers for predicting MS progression within the first year.
To assess prognostic factors for a second clinical episode or MRI changes post-CIS.

Main Methods:

Retrospective analysis of 46 patients with CIS.
Clinical and imaging follow-up for one year.
Neuroradiologist assessment of MRI scans for lesion count, location, and size.

Main Results:

54% of CIS patients progressed to MS within one year.
Lesion location (temporal, occipital, perpendicular to corpus callosum) and size (>0.75 cm) were associated with recurrence.
A combination of >13 lesions, maximal lesion length >0.75 cm, and perpendicular lesions increased MS conversion risk 19-fold.

Conclusions:

MRI lesion characteristics (number, location, size) are significant predictors of MS development after CIS.
These findings aid in risk stratification for patients experiencing CIS.
Closer monitoring is recommended for high-risk individuals to manage potential MS progression.