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Updated: Feb 7, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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Left Atrial Appendages Occlusion: Current Status and Prospective

Sharan Prakash Sharma1, Peter Park1, Dhanunjaya Lakkireddy2

  • 1Kansas City Heart Rhythm Institute, Overland Park, KS, USA.

Korean Circulation Journal
|August 4, 2018
PubMed

Insights

Left atrial appendage occlusion (LAAO) offers an alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF) patients with bleeding risks. While promising, device thrombosis remains a concern, necessitating further research on comparative effectiveness and optimal patient selection.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Atrial fibrillation (AF) poses a significant stroke risk, with oral anticoagulation (OAC) being a primary preventive measure.
  • Bleeding complications limit OAC use in a substantial proportion of AF patients.
  • The left atrial appendage (LAA) is a common source of emboli in nonvalvular AF.

Purpose of the Study:

  • To review the current evidence on the efficacy and safety of various left atrial appendage occlusion (LAAO) devices.
  • To explore the future directions for LAAO research and clinical application.

Main Methods:

  • Review of available randomized controlled trials and observational data on LAAO devices.
  • Analysis of long-term outcomes and complications associated with LAAO.
  • Discussion of comparative effectiveness and patient selection criteria.

Main Results:

  • LAAO provides an alternative stroke prophylaxis for AF patients unable to tolerate OAC.
  • Watchman and Amulet are commonly used LAAO devices, with limited randomized data for some.
  • Long-term data suggest promising results, but device-related thrombosis is a notable complication.

Conclusions:

  • LAAO is a viable alternative for stroke prevention in select AF patients.
  • Further research is needed on comparative effectiveness, optimal patient selection, and post-procedural management.
  • Addressing device-related thrombosis is crucial for improving LAAO outcomes.

Keywords:
AmuletAtrial fibrillationLariatLeft atrial appendage occlusionWatchman

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