Proton Transfer at the Interaction Interface of Graphene Oxide

Proton transfer plays a crucial role in a variety of biological phenomena. The transformation of nanomaterials in the environment and biology makes probing the potential proton transfer between nanomaterials and biomolecules a crucial issue, but it still remains a significant challenge. Here, we report proton transfer at the interface of graphene oxide (GO) by studying the GO-induced vibrational changes of interfacial water and carboxyl-terminated self-assembled monolayer (SAM) with surface-enhanced infrared absorption spectroscopy. In addition to simply acting as a macromolecular buffer in solution, the GO sheet behaves as a two-dimensional hydrogen-bonded exchangeable proton pool to dissociate and transfer protons at the interface with a suitable Brønsted base pair, which may bear a significant potential toxic origin for biological systems with proton-coupled reactions.