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TP53 polymorphisms in smokers' and nonsmokers' pericoronal follicles of asymptomatic impacted third molars
E Burhanoglu1, M C Aksoy2, P A Kosar3
1Private Practice, Oral Maxillofacial Surgeon, Balıkesir, Turkey.
Background And Purpose:
The investigators designed and implemented a prospective cohort study composed of smoking and nonsmoking patients with asymptomatic fully impacted mandibular third molars. The objective of the paper was to evaluate 21 single-nucleotide polymorphisms (SNP) on the TP53 gene in smokers' (S) and nonsmokers' (NS) pericoronal follicles of asymptomatic impacted third molars.
Materials And Methods:
Matrix-assisted desorption/ionization time of the flight mass spectrometry was used for SNP analysis of 21 regions in the TP53 gene. Descriptive statistics and Chi-square tests were computed with a P value of 0.05.
Results:
: Ten of the 21 SNPs related to oral pathologies according to NCBI dbSNP, were detected; in these, the genotypic frequencies showed no differences between the S and NS groups (P > 0.05). The results showed a high ratio of SNPs without correlation between smoking and TP53 gene status.
Conclusion:
Further studies should examine the entire TP53 gene to elucidate how smoking affects it in larger study populations.