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Updated: Feb 7, 2026

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
Published on: May 22, 2019
Involvement of X-chromosome Reactivation in Augmenting Cancer Testis Antigens Expression: A Hypothesis
Chang Liu1, Bin Luo2,3, Xiao-Xun Xie2,3
1Department of Neurosurgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Abstract:
Cancer testis antigens (CTAs) are attractive targets for tumor immunotherapy because of their tumor-specific expression. Since more than half of confirmed CTAs are located on the X-chromosome, we asked whether there is a link between CTA expression and X-chromosomes. Recent reports have shown that reactivation of the inactive X-chromosome, known as X-chromosome reactivation (XCR), a unique phenomenon that exists in many high-risk tumors in women, can transform the expression of many X-linked genes from monoallelic to biallelic. In this review, we discuss the link between CTA and XCR with the hopes of providing some novel insights into tumor biology.
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