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Updated: Feb 7, 2026

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
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Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

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PP2A Inhibits Cervical Cancer Cell Migration by Dephosphorylation of p-JNK, p-p38 and the p-ERK/MAPK Signaling

Hong-Yun Zheng1,2, Fu-Jin Shen3, Yong-Qing Tong4,5

  • 1Department of Clinical Laboratory, Wuhan, 430060, China.

Current Medical Science
|August 4, 2018
PubMed

Insights

Protein phosphatase 2A (PP2A) levels are reduced in cervical cancer, inhibiting cell migration and invasion. Restoring PP2A activity may offer a therapeutic strategy for cervical cancer by impacting key signaling pathways and MMP-9.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Protein phosphatase 2A (PP2A) is implicated in cancer development.
  • The specific role of PP2A in cervical cancer progression remains unclear.

Purpose of the Study:

  • To investigate the role and significance of PP2A in cervical cancer development.
  • To explore the potential of PP2A as a therapeutic target in cervical cancer.

Main Methods:

  • Serum PP2A levels measured by ELISA in cervical cancer patients and controls.
  • PP2A activity, mRNA, and protein levels analyzed in cervical cancer and chronic cervicitis tissues.
  • Cell migration and invasion assays (wound healing, Transwell) performed on HeLa cells with PP2A modulation.
  • MAPK signaling pathway activation and MMP-9 levels assessed.

Main Results:

  • Significantly reduced serum PP2A levels observed in cervical cancer patients.
  • Decreased PP2A activity, mRNA, and protein levels found in cervical cancer tissues.
  • PP2A upregulation inhibited HeLa cell migration; downregulation promoted it.
  • PP2A activation suppressed actin remodeling, MAPK (p-JNK, p-p38, p-ERK) activity, and MMP-9 levels, thereby inhibiting cell migration and invasion.

Conclusions:

  • PP2A activity and expression are significantly diminished in cervical cancer.
  • PP2A activation inhibits cervical cancer cell migration and invasion.
  • PP2A may exert its effects by modulating the MAPK signaling pathway and MMP-9 expression.
  • PP2A represents a potential therapeutic target for cervical cancer treatment.
Keywords:
HeLa cellsmigrationmitogen-activated protein kinasesprotein phosphatase 2A

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