Prognostic Value of Neutrophil to Lymphocyte Ratio for In-hospital Mortality in Elderly Patients with Acute...

Area of Science:

• Cardiology
• Inflammation Research
• Geriatric Medicine

Background:

• Coronary artery disease (CAD) is a complex condition where inflammation is a key factor.
• Predicting in-hospital mortality in elderly patients with acute myocardial infarction (AMI) is crucial for effective management.
• Inflammatory markers like the neutrophil-to-lymphocyte ratio (NLR) and risk scores such as the Global Registry of Acute Coronary Events (GRACE) score warrant investigation for prognostic value.

Purpose of the Study:

• To investigate the association between inflammatory markers (NLR, GRACE score) and in-hospital mortality in elderly AMI patients.
• To explore the prognostic value of NLR and GRACE score for predicting outcomes in this demographic.

Main Methods:

• Retrospective analysis of 1000 consecutive CAD patients, divided into elderly (≥60 years) and younger (<60 years) groups.
• Assessment of laboratory and clinical characteristics, including calculation of NLR and GRACE score.
• Comparison of NLR and GRACE scores between different patient subgroups (e.g., myocardial infarction types, risk strata) and survival outcomes.

Main Results:

• Elderly patients with myocardial infarction (NSTEMI/STEMI) showed significantly higher NLR compared to those with unstable or stable angina.
• NLR was significantly elevated in elderly AMI patients versus younger counterparts and higher in high-risk GRACE score groups.
• Both elevated NLR and GRACE score were significantly associated with in-hospital death; ROC analysis identified optimal cut-off values for predicting mortality.

Conclusions:

• An elevated neutrophil-to-lymphocyte ratio (NLR) is a potential predictor of in-hospital mortality in elderly patients experiencing acute myocardial infarction.
• The NLR and GRACE score demonstrate prognostic value for identifying elderly AMI patients at higher risk of in-hospital death.