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Updated: Feb 7, 2026

Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Ligand-Free Bioinspired Suzuki-Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep
Giuseppe Dilauro1, Sergio Mata García2, Donato Tagarelli1
1Dipartimento di Farmacia-Scienze del Farmaco, Consorzio C.I.N.M.P.I.S., Università di Bari "Aldo Moro", Via E. Orabona 4, I-, 70125, Bari, Italy.
Abstract:
Pd-catalyzed Suzuki-Miyaura cross-coupling between (hetero)aryl halides (Cl, Br, I) and versatile, moisture-stable mono- and bifunctional potassium aryltrifluoroborates proceeded efficiently and chemoselectively in air and under generally mild conditions; a catalyst loading as low as 1 mol % combined with Na2 CO3 as a base in choline chloride/glycerol (1:2) deep eutectic solvent (DES) was used as a sustainable and environmentally responsible medium. The catalyst, base, and DES were easily and successfully recycled up to six times with an E-factor as low as 8.74. Valuable biaryls and terphenyl derivatives were furnished in yields of up to 98 %; over 50 reactions were compared and discussed. The methodology was applied for the synthesis of the nonsteroidal anti-inflammatory drugs Felbinac and Diflunisal.
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