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Updated: Feb 7, 2026

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
Published on: September 14, 2017
Resident Endothelial Progenitors Make Themselves at Home
Karen K Hirschi1, Elisabetta Dejana2
1Departments of Medicine, Genetics, and Biomedical Engineering, Yale Cardiovascular Research Center and Yale Stem Cell Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Quiescent endothelial stem cells reside within blood vessels and activate upon injury. These cells show potential for therapeutic applications in regenerative medicine.
Area of Science:
- Vascular biology
- Regenerative medicine
- Cellular biology
Background:
- Vascular endothelial cells perform essential functions, adapting to their microenvironment.
- Recent research indicates the presence of quiescent endothelial stem/progenitor cells within blood vessels.
Purpose of the Study:
- To explore the potential of endothelial stem/progenitor cells for therapeutic applications.
- To understand the activation mechanisms of these cells in response to vascular injury.
Main Methods:
- Review of recent scientific literature.
- Analysis of studies on endothelial cell behavior and stem/progenitor cell populations.
Main Results:
- Evidence suggests endothelial stem/progenitor cells are quiescent within blood vessels.
- These cells are activated following vascular injury.
Conclusions:
- Endothelial stem/progenitor cells represent a promising target for therapeutic strategies.
- Harnessing these cells could lead to novel regenerative approaches for vascular diseases.
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