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Related Concept Videos

Quality Control01:05

Quality Control

2.7K
Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
2.7K
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

1.3K
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
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Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

5.3K
ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
5.3K
Quality Assurance01:19

Quality Assurance

2.4K
Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
2.4K
Quality of Water01:19

Quality of Water

572
In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
572
Pulse amplitude and quality01:17

Pulse amplitude and quality

3.2K
Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
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Related Experiment Video

Updated: Feb 7, 2026

Studying the Protein Quality Control System of D. discoideum Using Temperature-controlled Live Cell Imaging
06:09

Studying the Protein Quality Control System of D. discoideum Using Temperature-controlled Live Cell Imaging

Published on: December 2, 2016

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Quality Control of Orphaned Proteins.

Szymon Juszkiewicz1, Ramanujan S Hegde1

  • 1MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

Molecular Cell
|August 4, 2018
PubMed
Summary

Cells manage billions of proteins within compartments and complexes. This review explores how cells minimize orphaned proteins, their quality control, and the impact of protein mislocalization on health and disease.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Eukaryotic cells contain billions of proteins organized into sub-cellular compartments and protein complexes.
  • Proper protein localization and complex assembly are vital for cellular function.
  • Orphaned proteins, failing correct segregation or assembly, pose challenges to cellular organization.

Purpose of the Study:

  • To review the cellular strategies for minimizing orphaned proteins.
  • To discuss the quality control mechanisms that identify and manage orphaned proteins.
  • To explore the consequences of excess orphaned proteins on protein homeostasis and disease.

Main Methods:

  • This is a review article, synthesizing existing research on protein organization and quality control.

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Rapid Assessment of Membrane Protein Quality by Fluorescent Size Exclusion Chromatography

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Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution

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Related Experiment Videos

Last Updated: Feb 7, 2026

Studying the Protein Quality Control System of D. discoideum Using Temperature-controlled Live Cell Imaging
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Studying the Protein Quality Control System of D. discoideum Using Temperature-controlled Live Cell Imaging

Published on: December 2, 2016

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Rapid Assessment of Membrane Protein Quality by Fluorescent Size Exclusion Chromatography
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  • Literature search and analysis of studies related to protein trafficking, complex formation, and cellular quality control pathways.
  • Discussion of experimental evidence and theoretical models concerning orphaned proteins.

    • Main Results:

    • Cells employ sophisticated mechanisms to ensure correct protein localization and complex formation.
    • Quality control systems actively recognize and address mislocalized or unassembled proteins.
    • Accumulation of orphaned proteins disrupts protein homeostasis and is linked to various diseases.

    Conclusions:

    • Minimizing orphaned proteins is a critical cellular challenge requiring robust quality control.
    • Dysregulation of protein organization and quality control contributes to cellular dysfunction and disease pathogenesis.
    • Understanding orphaned protein dynamics offers insights into cellular health and disease mechanisms.