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Age-related changes in the relationship between visual exploration and hippocampal activity
Zhong-Xu Liu1, Kelly Shen1, Rosanna K Olsen2
1Rotman Research Institute, Baycrest, Toronto, Ontario, Canada M6A 2E1.
Neuropsychologia
|August 4, 2018
Summary
Older adults explore faces more but show weaker memory system coupling. This age-related decline impacts binding visual information for memory formation.
Area of Science:
- Cognitive Neuroscience
- Neuroimaging
- Aging Research
Background:
- Age-related memory decline is a significant concern.
- Visual sampling behavior, particularly gaze fixations, is linked to hippocampal activity in younger adults, suggesting oculomotor-memory system coupling.
- The impact of aging on this coupling is not well understood.
Purpose of the Study:
- To investigate how aging affects the relationship between visual exploration and neural activity in memory-related brain regions.
- To compare visual behavior and hippocampal/FFA activation between younger and older adults during a face processing task.
Main Methods:
- Employed a face processing task previously used with younger adults.
- Compared visual exploration (number of gaze fixations) and neural activation (hippocampus, fusiform face area - FFA) in older and younger adults.
- Assessed responses to novel faces and repetition suppression effects.
Main Results:
- Older adults exhibited increased visual exploration (more gaze fixations) compared to younger adults.
- The coupling between visual exploration and neural responses in the hippocampus and FFA was weaker in older adults.
- Older adults showed reduced responses to novel faces and a diminished repetition suppression effect in these brain regions.
Conclusions:
- The capacity to integrate visual information into memory representations declines with aging.
- Aging alters the coupling between visual sampling and neural processing in the ventral visual stream and medial temporal lobe.
- These findings provide novel insights into the neural mechanisms of age-related memory impairment.
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