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Updated: Feb 7, 2026

Isolation and Primary Culture of Rat Hepatic Cells
Published on: June 29, 2012
Primary hepatic neuroendocrine neoplasm: Long-time surgical outcome and prognosis
Changying Shi1, Qian Zhao, Binghua Dai
1Department of Hepatobiliary Surgery Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Abstract:
Primary hepatic neuroendocrine neoplasms (PHNENs) represent a kind of rare liver tumor and its clinical features and prognosis remain unclear. This study aims to reveal the long-term therapeutic outcome of PHNEN and to present its prognostic feature.A retrospective designed, single-center study containing 22 patients with PHNENs receiving surgical resections was done. Clinical data were reviewed and long-term follow-up was updated. Survival analysis was tried to find the prognostic factors.Nine patients recurred (recurrence rate = 40.9%) and 6 patients died on the disease. The actual 1-, 3-, and 5-year recurrence-free survival rate were 86.4%, 63.6%, and 52.9%, respectively. The 1-, 3-, and 5-year overall survival rate were 95.5%, 81.8%, and 64.7%, respectively. Median overall survival for group G1, G2, and G3 were 69, 67, and 42 months, respectively.Patients with PHNEN can have a long survival after radical surgical resection, especially when the tumor proliferative grade exhibits lower (G1/2).
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