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Interleukin 1 is present in normal human epidermis.

C Hauser, J H Saurat, A Schmitt

    Journal of Immunology (Baltimore, Md. : 1950)
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Human epidermis contains interleukin 1 (IL-1)-like molecules that stimulate fibroblasts and lymphocytes. These preformed IL-1 stores in the skin may play a significant role in vivo.

    Area of Science:

    • Immunology
    • Dermatology
    • Cell Biology

    Background:

    • Interleukin 1 (IL-1) is a key cytokine involved in immune responses.
    • The presence and function of IL-1-like molecules in normal human epidermal tissue remain largely uncharacterized.

    Purpose of the Study:

    • To investigate the presence and characteristics of IL-1-like molecules in normal human epidermal tissue.
    • To compare IL-1-like activity in epidermal extracts with peripheral blood mononuclear cells (PBMC).

    Main Methods:

    • Epidermal tissue from 21 healthy individuals was processed using two methods.
    • Assays included prostaglandin E2 (PGE2) and collagenase stimulation of dermal fibroblasts, thymocyte comitogenic activity (lymphocyte activating factor; LAF), and gel filtration chromatography.
    • High-pressure liquid chromatography (HPLC) was used for further molecular characterization.

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    Main Results:

    • Epidermal extracts exhibited PGE2 and collagenase stimulatory activity, as well as LAF activity.
    • Removal of the horny layer reduced epidermal IL-1-like activity.
    • PBMC showed no detectable PGE2 activity unless cultured and stimulated, unlike epidermal tissue.
    • Gel filtration and HPLC identified IL-1-like molecules with molecular weights of approximately 30,000 and 17,000.

    Conclusions:

    • Normal human epidermis contains preformed IL-1-like molecules, potentially including a precursor.
    • These molecules possess fibroblast-stimulating and lymphocyte-activating properties.
    • The release of these epidermal IL-1 stores may be significant in physiological and pathological processes in vivo.