Related Experiment Video
Updated: Feb 7, 2026
06:19
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
1.5K
Responsiveness of histological disease activity indices in ulcerative colitis: a post hoc analysis using data from
Vipul Jairath1, Laurent Peyrin-Biroulet2, Guangyong Zou1
1Robarts Clinical Trials Inc., London, Ontario, Canada.
Gut
|August 5, 2018
Summary
Four histological indices for ulcerative colitis (UC) disease activity showed similar reliability and responsiveness in a clinical trial. These validated tools aid in assessing treatment effectiveness for UC patients.
Area of Science:
- Gastroenterology
- Histopathology
- Clinical Trial Analysis
Background:
- Accurate histological assessment of ulcerative colitis (UC) disease activity is crucial for treatment evaluation.
- Existing histological indices require validation for standardized, centralized assessment.
Purpose of the Study:
- To evaluate the reliability and responsiveness of four validated histological disease activity indices in UC.
- To assess the performance of Geboes (GS), modified Riley (MRS), Robarts Histopathology (RHI), and Nancy Histological (NHI) indices.
Main Methods:
- Four blinded pathologists assessed UC disease activity using GS, MRS, RHI, NHI, and a Visual Analogue Scale in a phase II ozanimod trial.
- Reliability was measured using intraclass correlation coefficients (ICCs).
- Responsiveness was evaluated using longitudinal validity, standardized effect size (SES), and receiver operating characteristic (AUROC) curves.
Main Results:
- Inter-rater reliability for all histological indices was substantial to almost perfect (ICC > 0.61).
- Responsiveness was moderate to large (SES estimates > 0.5), with similar discriminative ability (AUROC range: 0.608–0.649).
- Specific SES estimates varied based on the criterion for change (treatment assignment or Mayo score decrease).
Conclusions:
- All four evaluated histological indices demonstrated comparable reliability and responsiveness.
- These validated indices can be effectively used for centralized assessment of UC disease activity.
More Related Videos
Related Concept Videos
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.0K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.0K
01:12Statistical Software for Data Analysis and Clinical Trials
1.6K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.6K
01:29Drugs for Treatment of Ulcerative Colitis in IBD
527
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
527
01:28Peptic Ulcer Disease II: Pathophysiology
2.1K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
2.1K
01:30Peptic Ulcer Disease I: Introduction
856
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
856
02:39Indicators
61.0K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
61.0K