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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.4K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Related Experiment Video

Updated: Feb 7, 2026

Acupuncture in a Rat Model of Asthma
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Neutrophil ghosts worsen asthma.

Marsha Wills-Karp1

  • 1Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Science Immunology
|August 5, 2018
PubMed
Summary

Neutrophil cytoplasts contribute to severe asthma by enhancing T helper 17-mediated inflammation. This finding highlights a new cellular mechanism driving airway inflammation in severe asthma.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Cell Biology

Background:

  • Severe asthma is a complex respiratory disease with limited treatment options.
  • T helper 17 (Th17) cells play a critical role in airway inflammation.
  • Neutrophils are key immune cells involved in asthma pathogenesis.

Purpose of the Study:

  • To investigate the role of neutrophil cytoplasts in Th17-mediated inflammation.
  • To explore the link between neutrophil cytoplasts and the severity of asthma.

Main Methods:

  • Analysis of immune cell populations in asthma patient samples.
  • In vitro experiments to assess the interaction between neutrophil cytoplasts and T cells.
  • Assessment of inflammatory markers associated with Th17 responses.

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Murine Model of Allergen Induced Asthma
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Murine Model of Allergen Induced Asthma
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Main Results:

  • Neutrophil cytoplasts were found to be present in severe asthma.
  • Neutrophil cytoplasts promote the differentiation and amplification of Th17 cells.
  • This amplification of Th17 responses correlates with asthma severity.

Conclusions:

  • Neutrophil cytoplasts are a significant factor in amplifying Th17-mediated inflammation in severe asthma.
  • Targeting neutrophil cytoplasts may offer a novel therapeutic strategy for severe asthma.