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[Inhalational analgosedation in the intensive care unit : Risk of malignant hyperthermia].

W Klingler¹, E Pfenninger²

¹Anästhesie und Intensivmedizin, SRH Kliniken Landkreis Sigmaringen GmbH, Hohenzollernstraße 40, 72488, Sigmaringen, Deutschland. anaesthesie.sigmaringen@klksig.de.

Medizinische Klinik, Intensivmedizin Und Notfallmedizin

|August 5, 2018

Summary

Malignant hyperthermia (MH), a dangerous reaction to inhaled anesthetics, can affect ventilated ICU patients. This review covers clinical and legal issues for physicians, patients, and families in Germany.

Keywords:

Dantrolene General anesthesia German Genetic Diagnostics Act Malignant hyperthermia Pharmacogenetics

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Area of Science:

Anesthesiology
Pharmacogenetics
Intensive Care Medicine

Background:

Analgosedation is a common practice for ventilated patients in intensive care units (ICUs).
Volatile anesthetics, typically used in surgical settings, can cause adverse effects in ICUs.
Malignant hyperthermia (MH) is a life-threatening pharmacogenetic reaction to these agents.

Purpose of the Study:

To inform intensive care unit (ICU) physicians about the clinical and legal challenges associated with malignant hyperthermia (MH).
To highlight the risks of pharmacogenetic reactions to inhalational anesthetics in non-surgical settings.

Main Methods:

Review of clinical guidelines and legal frameworks.
Discussion of case scenarios involving MH in the ICU.
Analysis of patient rights legislation and genetic diagnostics acts.

Main Results:

Malignant hyperthermia (MH) presents significant clinical challenges in the ICU setting.
Legal implications for healthcare providers and patients are substantial.
The German Genetic Diagnostics Act impacts MH management and patient rights.

Conclusions:

MH crises have serious consequences for doctors, patients, and their families.
Patient rights legislation, insurance, and employment issues require careful consideration.
Enhanced awareness and preparedness for MH in ICUs are crucial.