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Split-Face, Randomized, Placebo-Controlled, Double-Blind Study to Investigate Passive Versus Active Dermal Filler
Mário Jorge Freire Dos Santos1,2, Ricardo Carvalho3, Luis G Arnaut4
1Cirurgia Plástica, Centro Cirúrgico de Coimbra, Coimbra, Portugal.
Aesthetic Plastic Surgery
|August 5, 2018
Summary
High-frequency ultrasound effectively delivers hyaluronic acid (HA) for facial rejuvenation, offering a safe and non-invasive alternative to injections. This method showed significant improvements compared to placebo.
Area of Science:
- Aesthetics and Dermatology
- Medical Ultrasound Applications
- Biomaterial Delivery Systems
Background:
- Hyaluronic acid (HA) is a popular dermal filler, but traditional injection methods carry risks of complications.
- Increasing demand for HA facial rejuvenation necessitates exploring safer, non-invasive delivery alternatives.
- High-frequency high-intensity ultrasound (HFIU) presents a potential non-invasive method for delivering large molecules like HA.
Purpose of the Study:
- To evaluate the efficacy of HFIU for delivering HA for facial rejuvenation.
- To compare the outcomes of HFIU-delivered HA with a placebo in a controlled trial.
Main Methods:
- A randomized, double-blind, face-split trial involving 15 women (mean age 55).
- Five treatment sessions using HFIU to deliver either HA or placebo to different facial sides.
- Expert panel evaluation of pre- and post-treatment photographs to assess facial rejuvenation.
Main Results:
- The expert panel observed statistically significant facial rejuvenation on the HA-treated side compared to the placebo side (p < 0.0001).
- A noticeable difference in rejuvenation was consistently identified between the HA and placebo sides.
Conclusions:
- HFIU is a safe and effective modality for administering HA for facial rejuvenation.
- This non-invasive ultrasound-based approach yields unambiguous and significant aesthetic improvements.
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