Related Experiment Video
Updated: Feb 7, 2026
13:04
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
Published on: March 1, 2019
9.3K
Potential role of RAB6C-AS1 long noncoding RNA in different cancers
Abbas Salavaty1, Fatemeh Movahedi Motlagh2,3, Mehri Barabadi2
1Young Researchers and Elite Club, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Journal of Cellular Physiology
|August 5, 2018
Summary
The long noncoding RNA RAB6C-AS1 is often overexpressed in gastric cancer and may act as an oncogene or tumor suppressor depending on the cancer type. This suggests RAB6C-AS1 could be a biomarker for various cancers, including brain and prostate cancers.
Area of Science:
- Molecular Biology
- Genomics
- Cancer Research
Background:
- Long noncoding RNAs (lncRNAs) are crucial regulators of cellular processes, often via epigenetic mechanisms.
- Dysregulation of lncRNAs is implicated in various diseases, particularly cancer.
- This study focuses on the role of the RAB6C-AS1 lncRNA in different cancer types.
Purpose of the Study:
- To investigate the expression and potential roles of RAB6C-AS1 in cancer.
- To determine if RAB6C-AS1 is associated with gastric cancer progression.
- To explore the oncogenic or tumor-suppressive functions of RAB6C-AS1 in various cancers.
Main Methods:
- Real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) was used to analyze RAB6C-AS1 expression in gastric cancer samples.
- Bioinformatic analyses and utilization of public datasets were employed to assess RAB6C-AS1's association with different cancers.
- Systems biology approaches were used to understand the functional implications of RAB6C-AS1.
Main Results:
- RAB6C-AS1 was found to be overexpressed in 40% of gastric cancer specimens.
- Overexpression of RAB6C-AS1 correlated with higher tumor grades in gastric cancer.
- Bioinformatic analysis indicated RAB6C-AS1 may act as an oncogene in prostate and breast cancers, but as a tumor suppressor in brain tumors.
Conclusions:
- RAB6C-AS1 is frequently overexpressed in gastric cancer.
- RAB6C-AS1 exhibits tissue-specific functions, potentially acting as an oncogene or tumor suppressor.
- RAB6C-AS1 shows promise as a biomarker for malignancies like prostate and brain cancers, with notable prognostic value in lower-grade gliomas.
More Related Videos
07:35Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
Published on: December 1, 2023
1.2K
06:36A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
Published on: April 24, 2015
11.4K
Related Concept Videos
01:53RNA Stability
35.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
01:23Types of RNA
72.9K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.9K
02:36Transfer RNA Synthesis
13.4K
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
13.4K
01:23RNA Interference
28.1K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.1K
01:23RNA Structure
79.2K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.2K
01:32RNA Splicing
60.7K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.7K