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Cisplatin neuropathy with Lhermitte's sign
Journal of Neurology, Neurosurgery, and Psychiatry
|January 1, 1986
Summary
Cisplatin chemotherapy can cause delayed neurological side effects, including Lhermitte's sign and peripheral neuropathy, appearing after treatment completion. Increased cisplatin use may lead to more frequent proprioceptive and myelopathic issues in cancer patients.
Area of Science:
- Neuroscience
- Oncology
- Pharmacology
Background:
- Cisplatin (cis-diamminedichloroplatinum II) is a widely used chemotherapeutic agent for various cancers.
- Effective cancer treatment often involves balancing efficacy with potential toxicities.
Observation:
- Three patients receiving cisplatin chemotherapy developed Lhermitte's sign and peripheral neuropathy.
- These neurological toxicities manifested after the cessation of cisplatin treatment.
Findings:
- Cisplatin-induced neurotoxicity can present with delayed onset, appearing post-treatment.
- Lhermitte's sign and peripheral neuropathy are notable neurological sequelae.
Implications:
- The increasing application of cisplatin necessitates awareness of its potential for delayed neurological side effects.
- Clinicians should monitor patients for proprioceptive and myelopathic symptoms following cisplatin therapy.
- Further research into mitigating cisplatin-induced neurotoxicity is warranted.