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Related Concept Videos

Amino acids03:42

Amino acids

105.7K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
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Increasing Function01:18

Increasing Function

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An increasing function exhibits a rise in output values as input values increase. This behavior is depicted graphically as a curve or line that slopes upward from left to right. Such a function satisfies the condition that if x1 < x2, then f(x1) < f(x2), indicating that the function values grow with increasing inputs. This concept is fundamental in understanding growth trends across various domains, such as population dynamics, financial investments, or resource consumption.The...
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Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Increased pulse rate01:17

Increased pulse rate

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Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
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Radical Chain-Growth Polymerization: Chain Branching01:17

Radical Chain-Growth Polymerization: Chain Branching

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The skeletal structure of polymers synthesized via radical polymerization is always branched. For example, the polymerization of ethylene by radical polymerization results in a low-density grade of polyethylene with a heavily branched skeletal structure. Here, the radical site abstracts hydrogen from the growing chain, and the radical site shifts from the end (a primary carbon center) to anywhere within the growing chain (a secondary carbon center). Consequently, the part of the chain from the...
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Amino Acid Catabolism01:18

Amino Acid Catabolism

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Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Increased Levels Of Branched-chain Amino Acid Associated With Increased Risk Of Pancreatic Cancer In A Prospective Case-control Study Of A Large Cohort.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Increased Levels Of Branched-chain Amino Acid Associated With Increased Risk Of Pancreatic Cancer In A Prospective Case-control Study Of A Large Cohort.

Related Experiment Video

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

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Increased Levels of Branched-Chain Amino Acid Associated With Increased Risk of Pancreatic Cancer in a Prospective Case-Control Study of a Large Cohort.

Ryoko Katagiri1, Atsushi Goto1, Takashi Nakagawa2

  • 1Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

Gastroenterology
|August 5, 2018

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
MetabolitesMetabolomePancreasTumorigenesis

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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

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Related Experiment Videos

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
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High branched-chain amino acid (BCAA) levels in blood are linked to a higher risk of pancreatic cancer. This association is particularly strong when elevated BCAAs are detected at least 10 years before diagnosis.

Area of Science:

  • Metabolic markers
  • Cancer epidemiology
  • Biomarker discovery

Background:

  • Pancreatic cancer risk assessment requires reliable biomarkers.
  • Elevated branched-chain amino acids (BCAAs) have been preliminarily linked to pancreatic cancer.
  • Prospective studies are needed to confirm the association between plasma BCAA levels and pancreatic cancer risk.

Purpose of the Study:

  • To investigate the association between plasma branched-chain amino acid (BCAA) levels and the risk of developing pancreatic cancer.
  • To evaluate if the timing of BCAA level detection influences the association with pancreatic cancer risk.

Main Methods:

  • A nested case-control study was conducted within the Japan Public Health Center-based prospective study cohort (30,239 participants, aged 40-69).
  • 170 pancreatic cancer cases were matched with 2 controls each, considering age, gender, region, and fasting status.
  • Conditional logistic regression models were used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for pancreatic cancer risk based on plasma BCAA levels.

    • Main Results:

    • Increased plasma BCAA levels were significantly associated with an elevated risk of pancreatic cancer.
    • The highest quartile of BCAA levels showed an OR of 2.43 (95% CI 1.21-4.90) compared to the lowest quartile.
    • The association was more pronounced for samples collected at least 10 years before diagnosis (OR per SD 1.60) versus less than 10 years (OR per SD 1.16).

    Conclusions:

    • Elevated plasma branched-chain amino acid (BCAA) levels are associated with an increased risk of pancreatic cancer.
    • The predictive value of BCAAs for pancreatic cancer risk is stronger when detected a decade or more prior to diagnosis.
    • These findings support BCAAs as potential early biomarkers for pancreatic cancer risk stratification.