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Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
Published on: March 1, 2024
Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical
Rahmet Parilti1, Jérémie Caprasse2, Raphaël Riva2
1CERM, CESAM Research Unit, University of Liege, 13, Allée du Six Août, B-4000 Liege, Belgium; School of Chemistry, University of Nottingham, University Park, NG7 2RD Nottingham, United Kingdom.
Abstract:
Antimicrobial peptide loaded poly(2-hydroxyethyl methacrylate) particles were synthesized in supercritical carbon dioxide via one-pot free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate and a cross-linker. Discrete particles with a well-defined spherical morphology and a diameter as low as 450 nm have been obtained in mild conditions. The encapsulation and release of the peptide were confirmed by antimicrobial tests that demonstrated for the first time a sustained release of the peptide from poly(2-hydroxyethyl methacrylate) microgels prepared by one-pot dispersion polymerization in supercritical carbon dioxide and then dispersed in water.
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