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Related Experiment Video

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Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification
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A New Three-Dimensional Echocardiography Method to Quantify Aortic Valve Calcification.

Thomas d'Humières1, Laureline Faivre1, Elie Chammous2

  • 1Department of Radiology, AP-HP, Henri-Mondor Teaching Hospital, Créteil, France; Department of Cardiovascular Medicine, AP-HP, Henri-Mondor Teaching Hospital, Créteil, France; Department of Pathology, AP-HP, Henri-Mondor Teaching Hospital, Créteil, France.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|August 6, 2018
PubMed
Summary
This summary is machine-generated.

Three-dimensional transthoracic echocardiography (3D-TTE) can quantify aortic valve calcification (AVC) at the bedside. This ultrasound method shows fair correlation with MDCT and pathological findings, offering a feasible alternative for AVC assessment.

Keywords:
3D echocardiographyAortic valve stenosisCalcium scoring

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Echocardiography

Background:

  • Aortic valve calcification (AVC) quantification is typically performed using multidetector computed tomography (MDCT).
  • There is a need for a bedside method to assess AVC.

Purpose of the Study:

  • To evaluate the feasibility of using three-dimensional transthoracic echocardiography (3D-TTE) for bedside quantification of AVC.
  • To compare 3D-TTE derived AVC measurements with MDCT and pathological findings.

Main Methods:

  • 94 patients underwent both MDCT and 3D-TTE for aortic valve assessment.
  • Apical 3D full-volume datasets were acquired, and a region-growing algorithm computed 3D transthoracic echocardiographic AVC (AVC-3DEcho).
  • Comparisons were made with MDCT and, in a subgroup of 22 surgical patients, with explanted valve pathology.

Main Results:

  • AVC-3DEcho showed fair correlations with MDCT (r=0.61) and pathological calcium load (r=0.81).
  • AVC-3DEcho accurately identified severe aortic stenosis (AUC=0.94) and was associated with paravalvular regurgitation.
  • Intraobserver and interobserver variability for AVC-3DEcho were 4.2% and 8.9%, respectively.

Conclusions:

  • 3D-TTE is a feasible bedside method for quantifying AVC.
  • AVC-3DEcho correlates with pathological calcium burden and MDCT.
  • This technique offers a promising alternative for assessing AVC in clinical practice.