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Synovial sarcoma: Do children do better?

Maria Anna Smolle1, Michael Parry2, Lee Jeys2

  • 1Department of Orthopaedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036 Graz, Austria.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|August 6, 2018
PubMed
Summary
This summary is machine-generated.

Younger patients with synovial sarcoma (a type of soft tissue sarcoma) have a better prognosis. Small tumor size and young age are key factors for improved cancer-specific survival (CSS).

Keywords:
Cancer-specific survivalPrognsotic factorsSoft tissue sarcomaSynovial sarcoma

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Area of Science:

  • Oncology
  • Pediatric Oncology
  • Soft Tissue Sarcomas

Background:

  • Synovial sarcoma, a soft tissue sarcoma (STS), often affects young patients, but diagnosis can be delayed due to varied symptoms.
  • Previous studies suggest children may have a better prognosis than adults with this condition.

Purpose of the Study:

  • To compare clinical presentation and outcomes between pediatric and adult patients with synovial sarcoma.
  • To identify prognostic factors influencing cancer-specific survival (CSS) in synovial sarcoma.

Main Methods:

  • Retrospective analysis of 248 patients treated between 1982 and 2014.
  • Inclusion of demographic, pathology, and treatment data; median follow-up of 5.2 years.
  • Multivariate analysis to determine factors affecting CSS.

Main Results:

  • No significant differences in symptom duration, tumor size, site, grade, or location between children and adults.
  • Five-year CSS rates were 75.5% for adults and 89.0% for children; 10-year CSS rates were 56.1% and 82.2%, respectively (p=0.026).
  • Large tumor size and older patient age were independently associated with worse CSS.

Conclusions:

  • Synovial sarcoma presents similarly in children and adults, with no key differences in tumor characteristics.
  • Small tumor size and young patient age are independent positive prognostic factors for CSS in synovial sarcoma.