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A Clinician's Guide to Next Generation Imaging in Patients With Advanced Prostate Cancer (RADAR III).

E David Crawford1, Phillip J Koo2, Neal Shore3

  • 1University of Colorado , Aurora , Colorado.

The Journal of Urology
|August 6, 2018
PubMed
Summary

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This summary is machine-generated.

Next-generation imaging helps detect advanced prostate cancer recurrence earlier, guiding treatment decisions. These advanced techniques improve patient outcomes by identifying previously undetectable metastases.

Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • The treatment landscape for advanced prostate cancer has significantly improved survival for patients with both castration-naive and castration-resistant disease.
  • Novel next-generation imaging techniques are emerging, impacting diagnostic and therapeutic strategies.
  • Clinicians require guidance on integrating these advanced imaging modalities into treatment planning, especially with limited correlative therapeutic data.

Purpose of the Study:

  • To provide guidance on the use of next-generation imaging for staging prostate cancer.
  • To assess the impact of next-generation imaging on treatment options through earlier disease detection.

Main Methods:

  • The RADAR (Radiographic Assessments for Detection of Advanced Recurrence) III Group convened to develop recommendations.
Keywords:
clinical decision-makingdiagnostic imagingneoplasm metastasispractice guidelineprostatic neoplasms

Related Experiment Videos

  • The group reviewed available data and clinical experience regarding next-generation imaging in prostate cancer.
  • Discussions focused on the implications of earlier disease detection on treatment strategies.

    • Main Results:

    • Progression to metastatic disease is a critical event in advanced prostate cancer management.
    • Next-generation imaging can detect previously undetectable metastases, potentially redefining prostate cancer staging.
    • Earlier detection of metastases may enable more timely and effective systemic or local treatments, improving patient outcomes.

    Conclusions:

    • Next-generation imaging is recommended for select patients with suspected disease progression based on biomarkers, comorbidities, or symptoms.
    • 18F-fluciclovine and 68Ga-PSMA PET/CT are currently favored agents due to their availability, specificity, and sensitivity.
    • Ongoing research into new imaging technologies promises enhanced diagnostic accuracy and therapeutic options, improving the detection of micrometastases and patient outcomes.