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Updated: Feb 7, 2026

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism
Published on: December 28, 2010
Precise theta burst transcranial magnetic stimulation selectively reduced duration-related mismatch negativity
Yingying Tang1, Chunwei Ying2, Junjie Wang3
1Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Key Laboratory of Embedded System and Service Computing (Tongji University), Ministry of Education, Shanghai, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China.
Background:
Mismatch negativity (MMN) is a typical event-related potential component reflecting pre-attentive processing. MMN impairment, especially reduced duration-related MMN (dMMN), has been suggested as a potential predictive biomarker for the onset of schizophrenia.
Objective:
This study attempts to manipulate specific MMN activities using advanced neuroimaging-guided intermittent theta-burst stimulations (iTBS), which will be helpful to uncover the sources of MMN generation and contribute to the development of new clinical treatments.
Methods:
Twenty-four healthy volunteers were recruited and participated two-session modulations consisting of active and sham iTBS. ITBS was precisely delivered over individual right posterior superior temporal cortex (pSTG). Before and after each iTBS session, two MMN components evoked by duration and frequency deviants were quantified respectively.
Results:
A significant interaction of time and iTBS was observed on dMMN amplitudes, but not frequency-related MMN amplitudes. dMMN only decreased after active precise iTBS intervention, but did not after sham iTBS. The post effect of iTBS on dMMN was found in 16 of 20 subjects, suggesting a robust effect even at individual level. Furthermore, sLORETA analysis showed that the lateralization of STG activation was reversed after the active iTBS.
Conclusions:
We applied a precise strategy for neuroimaging-guided iTBS modulation over the right pSTG, which is promising in selectively modulating MMN for specific deviants.
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