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Gadolinium-based contrast agents in children.

Michael N Rozenfeld1, Daniel J Podberesky2

  • 1Department of Radiology, University of Arizona College of Medicine - Phoenix, 550 E. Van Buren St., Phoenix, AZ, 85004, USA. mikerozenfeld@email.arizona.edu.

Pediatric Radiology
|August 6, 2018
PubMed
Summary
This summary is machine-generated.

Gadolinium-based contrast agents (GBCAs) are widely used in medical imaging. While generally safe, gadolinium deposition in the brain is now recognized, with unknown clinical effects in patients with normal kidney function.

Keywords:
BrainChildrenContrastGadolinium-based contrast agentMagnetic resonance imagingNephrogenic systemic fibrosis

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Area of Science:

  • Radiology and Medical Imaging
  • Nephrology
  • Neurology

Background:

  • Gadolinium-based contrast agents (GBCAs) have been administered over 300 million times globally.
  • Previously considered very safe, the discovery of nephrogenic systemic fibrosis (NSF) raised safety concerns.
  • Gadolinium deposition in the brain is now detectable even in individuals with normal renal function.

Purpose of the Study:

  • To provide a comprehensive review of GBCAs.
  • To discuss the historical context and evolving understanding of GBCA safety.
  • To examine the potential risks associated with gadolinium deposition, particularly in pediatric populations.

Main Methods:

  • Literature review of studies on Gadolinium-based contrast agents.
  • Analysis of historical data regarding adverse events, including NSF.
  • Examination of recent findings on gadolinium deposition in the brain.

Main Results:

  • Gadolinium deposition occurs in the brain of individuals with normal renal function.
  • The clinical significance and potential effects of this deposition are currently unknown.
  • The overall risk of adverse reactions to GBCAs remains very low.

Conclusions:

  • Ongoing research is necessary to determine the clinical impact of gadolinium deposition in the brain.
  • A balanced perspective on GBCA risks and benefits is crucial for clinical practice.
  • This review offers insights from a pediatric radiologist's viewpoint on GBCA safety.