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Updated: Feb 7, 2026
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Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment
Published on: September 25, 2009
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Rupture limit evaluation of human cerebral aneurysms wall: Experimental study
Journal of Biomechanics
|August 7, 2018
Summary
Intracranial aneurysm rupture risk is linked to tissue rigidity. Ruptured aneurysms show soft tissue, while unruptured ones have stiff tissue, aiding rupture risk assessment.
Area of Science:
- Biomedical Engineering
- Materials Science
- Neurosurgery
Background:
- Intracranial aneurysm rupture poses a significant public health risk.
- Assessing individual rupture risk is a key objective in aneurysm research.
- Previous research focused on mechanical properties, this study investigates rupture limits.
Purpose of the Study:
- To investigate the rupture limit values of intracranial aneurysm tissues.
- To correlate mechanical properties with aneurysm rupture status and patient demographics.
- To enhance individual rupture risk assessment for intracranial aneurysms.
Main Methods:
- Aneurysmal tissues from 39 patients (24 unruptured, 15 ruptured) were tested using uniaxial tensile tests.
- Mechanical properties were analyzed using a Yeoh hyperelastic model.
- Tensile tests were conducted until sample rupture to determine stress and strain rupture limits.
Main Results:
- Strain rupture limit was consistently around 20%, independent of aneurysm status or gender.
- Tissue rigidity significantly influenced stretch and stress rupture limits.
- Ruptured aneurysms predominantly exhibited soft tissue, whereas unruptured aneurysms showed stiff tissue.
Conclusions:
- Aneurysm tissue rigidity is a critical factor in rupture mechanics.
- Soft tissues are associated with ruptured aneurysms, and stiff tissues with unruptured ones.
- These findings contribute to improved intracranial aneurysm rupture risk assessment.
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