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Related Concept Videos

What is the Cell Cycle?00:56

What is the Cell Cycle?

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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the...
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What is the Cell Cycle?01:04

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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
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The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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The most common elements in organic molecules, carbon, hydrogen, oxygen, nitrogen, sulfur, and phosphorus, are only available in the ecosystem in limited amounts. Therefore, these nutrients must be recycled through both biotic and abiotic components of the ecosystem, in processes generally called biogeochemical cycles.
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Analysis of Cell Cycle Position in Mammalian Cells
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Apicomplexa Cell Cycles: Something Old, Borrowed, Lost, and New.

Michael W White1, Elena S Suvorova1

  • 1Department of Global Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA.

Trends in Parasitology
|August 7, 2018
PubMed
Summary
This summary is machine-generated.

Apicomplexa parasites like Toxoplasma and Plasmodium have unique cell cycles. Understanding their replication mechanisms is key to controlling apicomplexan diseases.

Keywords:
ApicomplexaToxoplasma gondiicell cyclecyclin-dependent kinaseevolutionmitosis

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Area of Science:

  • Parasitology
  • Cell Biology
  • Molecular Biology

Background:

  • Parasite burden correlates with disease severity in Apicomplexa infections.
  • Apicomplexan pathogenesis is influenced by asexual stage growth rates.

Purpose of the Study:

  • To review recent advancements in understanding Apicomplexa parasite replication.
  • To elucidate the mitotic structures and cell cycle regulators essential for Apicomplexa proliferation.

Main Methods:

  • Literature review of recent research on Apicomplexa cell cycles.
  • Analysis of molecular mechanisms governing parasite replication.

Main Results:

  • Apicomplexa parasites exhibit highly unconventional cell cycles.
  • These cell cycles blend ancient and acquired elements for host adaptation.

Conclusions:

  • Deciphering Apicomplexa cell cycle regulation offers insights into parasite proliferation.
  • Understanding these unique mechanisms is crucial for developing novel therapeutic strategies against apicomplexan infections.