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B'reshith.

Ronald A Siegel1, Larry Brown2, Elazer R Edelman3

  • 1Departments of Pharmaceutics and Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 7, 2018
PubMed
Summary
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This essay explores the scientific and technological environment of the late 1970s and early 1980s, highlighting Bob Langer's early work in polymer-based macromolecule delivery and heparin removal for surgical safety.

Area of Science:

  • Biomedical Engineering
  • Polymer Science
  • Materials Science

Background:

  • The essay examines the scientific and technological milieu of the late 1970s and early 1980s.
  • It focuses on the foundational period of Langer Labs and Bob Langer's early career.
  • The context is set by the Hebrew word "b'reshith" (בְּרֵאשִׁית), meaning "in the beginning."

Observation:

  • Bob Langer demonstrated a remarkable ability to identify critical problems.
  • He fostered interdisciplinary collaboration to address these challenges.
  • This approach was evident from the inception of Langer Labs.

Findings:

  • Langer's early work centered on two key areas: controlled release of macromolecules from polymers and heparin removal.
  • Controlled release technologies aimed to precisely deliver therapeutic agents.
Keywords:
Early daysLanger labs

Related Experiment Videos

  • Heparin removal strategies focused on preventing uncontrolled bleeding during surgical procedures.

    • Implications:

    • Langer's foundational work laid the groundwork for significant advancements in drug delivery and surgical safety.
    • His interdisciplinary approach continues to inspire innovation in biomedical research.
    • The principles established in these early areas have broad applications in medicine and biotechnology.