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A case of pheochromocytoma with a marked decrease in catecholamine levels after rupture in which a good outcome was
Norimitsu Murai1, Tetsushi Azami1, Tatsuya Iida1
1Division of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, Yokohama, Kanagawa 227-8501, Japan.
Endocrine Journal
|August 7, 2018
Summary
Pheochromocytoma rupture led to spontaneous resolution of hypertension and hyperglycemia. Histopathology confirmed the rupture, revealing hemorrhagic necrosis and viable tumor cells, offering rare insights into this event.
Area of Science:
- Endocrinology
- Radiology
- Pathology
Background:
- Pheochromocytoma is a rare adrenal tumor causing hypertension and other symptoms due to excess catecholamine production.
- Documented cases of pheochromocytoma rupture with detailed clinical, imaging, and histopathological correlation are scarce.
Observation:
- A patient with uncontrolled hypertension and hyperglycemia presented with symptoms suggestive of pheochromocytoma.
- Abdominal CT revealed an adrenal mass; however, after spontaneous left flank pain, imaging showed changes consistent with tumor rupture, and hormone levels normalized.
Findings:
- Computed tomography (CT) demonstrated evolving changes in the adrenal mass, indicative of rupture and hemorrhage.
- Histopathological examination of the resected tumor confirmed pheochromocytoma with widespread hemorrhagic necrosis and viable tumor cells at the margins.
Implications:
- This case highlights the dynamic changes in imaging and hormone levels associated with pheochromocytoma rupture.
- Understanding these changes is crucial for accurate diagnosis and management of this rare clinical presentation.
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