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Cutaneous Bacteriological Profile in Patients with Pemphigus
K C Kiran1, J Madhukara2, Anil Abraham2
1Department of DVL, Dr. BR Ambedkar Medical College Hospital, Bengaluru, Karnataka, India.
Indian Journal of Dermatology
|August 7, 2018
Summary
Staphylococcus aureus is the most common skin bacteria in pemphigus patients, showing high sensitivity to certain antibiotics but resistance to others. This finding is crucial for managing infections in this autoimmune disease.
Area of Science:
- Dermatology
- Infectious Diseases
- Autoimmune Disorders
Background:
- Pemphigus is a severe autoimmune blistering disease.
- Septicemia, often from skin infections, is a primary cause of mortality in pemphigus patients.
Purpose of the Study:
- To investigate the bacteriological profile of skin infections in pemphigus patients.
- To identify common bacterial pathogens and their antibiotic susceptibility patterns.
Main Methods:
- Collected pus samples from infected pemphigus lesions between June 2013 and June 2014.
- Performed bacterial culture and antibiotic sensitivity testing.
- Analyzed data from 49 pemphigus patients.
Main Results:
- Staphylococcus aureus was the most frequently isolated organism (40.81%).
- Pseudomonas aeruginosa (12.24%) and Proteus mirabilis (6.12%) were also identified.
- S. aureus demonstrated 100% sensitivity to tetracycline, amikacin, chloramphenicol, and netilmicin, but significant resistance to penicillin and ciprofloxacin.
Conclusions:
- Staphylococcus aureus is the predominant pathogen in pemphigus skin infections.
- Antibiotic sensitivity patterns highlight effective treatments (tetracycline, amikacin, chloramphenicol, netilmicin) and resistance (penicillin, ciprofloxacin).
- Understanding these profiles is vital for effective patient management and preventing complications.
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